IGVL gene region usage correlates with distinct clinical presentation in IgM vs non-IgM light chain amyloidosis
Abstract
Patients with immunoglobulin M (IgM) light chain (AL) amyloidosis have a distinct clinical presentation compared with those with non-IgM amyloidosis. We hypothesized that differential immunoglobulin light-chain variable region (IGVL) gene usage may explain the differences in organ involvement, because IGVL usage correlates with organ tropism. IGVL usage was evaluated by mass spectrometry of amyloid deposits (IgM, n = 45; non-IgM, n = 391) and...
Paper Details
Title
IGVL gene region usage correlates with distinct clinical presentation in IgM vs non-IgM light chain amyloidosis
Published Date
Apr 20, 2021
Journal
Volume
5
Issue
8
Pages
2101 - 2105
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