Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly
Volume: 13, Issue: 1
Published: Jan 1, 2021
Abstract
Introduction Periodontal disease is a chronic, inflammatory bacterial dysbiosis that is associated with both Alzheimer's disease (AD) and Down syndrome. Methods A total of 48 elderly cognitively normal subjects were evaluated for differences in subgingival periodontal bacteria (assayed by 16S rRNA sequencing) between cerebrospinal fluid (CSF) biomarker groups of amyloid and neurofibrillary pathology. A dysbiotic index (DI) was defined at the...
Paper Details
Title
Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly
Published Date
Jan 1, 2021
Volume
13
Issue
1
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