Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material
Abstract
The world-first success of lipid nanoparticle (LNP)-based siRNA therapeutics (ONPATTRO®) promises to accelerate developments in siRNA therapeutics/gene therapy using LNP-type drug delivery systems (DDS). In this study, we explore the optimal composition of an LNP containing a self-degradable material (ssPalmO-Phe) for the delivery of oligonucleotides. siRNA or antisense oligonucleotides (ASO) were encapsulated in LNP with different lipid...
Paper Details
Title
Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material
Published Date
Apr 13, 2021
Journal
Volume
13
Issue
4
Pages
544 - 544
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History