Review paper
Integrating PARP Inhibitors Into Advanced Prostate Cancer Therapeutics
Abstract
DNA-damage repair (DDR) pathway mutations can sensitize cancer cells to a class of cancer therapeutics known as PARP inhibitors. Given that DDR alterations can be found in up to one-third of advanced prostate cancers, PARP inhibitors have recently been established in treatment-refractory settings. We provide an updated review of the clinical data supporting the 4 PARP inhibitors that have undergone the most investigation thus far in metastatic...
Paper Details
Title
Integrating PARP Inhibitors Into Advanced Prostate Cancer Therapeutics
Published Date
Mar 15, 2021
Journal
Pages
119 - 125
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