Su1436 Central Versus Peripheral Sites of Action of New Ghrelin Agonists on Gastrointestinal Prokinetic Activity

Background: Gastric dysmotility including delayed gastric emptying and decrease the electrical activity of the stomach is common in patients with long-standing diabetes mellitus (DM). These DM patients, some of them are diagnosed as diabetic gastroparesis, have several upper gastrointestinal (GI) symptoms such as nausea, vomiting, bloating and abdominal pain. However, the relationship between gastric dysmotility and GI symptoms has not been...