Internal medicine

Receptor

Anaphylaxis

Sensitization

Drug allergy

Population

Histamine

Immunoglobulin E

Antibody

Immunology

Allergy

Platelet-activating factor

Drug

Medicine

Pharmacology

Environmental health

Journal of Allergy and Clinical Immunology

Drug-induced anaphylaxis is a hyperacute reaction affecting multiple organs that can be of fatal consequence. Its incidence is increasing, consistent with a global increased sensitization to various allergens and drugs in the population. Few risk factors and mechanisms have been identified from human studies due to the rarity of anaphylactic events and their unpredictability. This systemic reaction is caused by the rapid release of a large range of functionally diverse mediators, including histamine and platelet-activating factor as the main drivers identified.

Mechanisms of human drug-induced anaphylaxis