Polyphenol and Cu2+ surface-modified chitin sponge synergizes with antibacterial, antioxidant and pro-vascularization activities for effective scarless regeneration of burned skin

• PAs-Cu 2+ modified chitin sponges could catalyze S-nitrosothiols to generate NO. • The sponges with antioxidant properties could protect cells from ROS injury. • The sponges exhibited antibacterial and pro-vascularization properties. • The sponges could accelerate wound healing and inhibit scar formation. Bacterial overgrowth and high oxidative stress often lead to burn wound infection, hyper-inflammation, and slowed wound healing, eventually...