Original paper
A PRC2-independent function for EZH2 in regulating rRNA 2′-O methylation and IRES-dependent translation
Abstract
Dysregulated translation is a common feature of cancer. Uncovering its governing factors and underlying mechanism are important for cancer therapy. Here, we report that enhancer of zeste homologue 2 (EZH2), previously known as a transcription repressor and lysine methyltransferase, can directly interact with fibrillarin (FBL) to exert its role in translational regulation. We demonstrate that EZH2 enhances rRNA 2'-O methylation via its direct...
Paper Details
Title
A PRC2-independent function for EZH2 in regulating rRNA 2′-O methylation and IRES-dependent translation
Published Date
Apr 1, 2021
Journal
Volume
23
Issue
4
Pages
341 - 354
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History