Original paper
Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation
Abstract
Endothelial barrier disruption and vascular leak importantly contribute to organ dysfunction and mortality during inflammatory conditions like sepsis and acute respiratory distress syndrome. We identified the kinase Arg/Abl2 as a mediator of endothelial barrier disruption, but the role of Arg in endothelial monolayer regulation and its relevance in vivo remain poorly understood. Here we show that depletion of Arg in endothelial cells results in...
Paper Details
Title
Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation
Published Date
Mar 26, 2021
Journal
Volume
24
Issue
3
Pages
677 - 693