Calibration of T₂ oximetry MRI for subjects with sickle cell disease

Purpose Cerebral T 2 oximetry is a non‐invasive imaging method to measure blood T 2 and cerebral venous oxygenation. Measured T 2 values are converted to oximetry estimates using carefully validated and potentially disease‐specific calibrations. In sickle cell disease, red blood cells have abnormal cell shape and membrane properties that alter T 2 oximetry calibration relationships in clinically meaningful ways. Previous in vitro works by two...