Perioperative therapy in renal cancer in the era of immune checkpoint inhibitor therapy

Purpose of review Immune checkpoint inhibitor (ICI) combination therapy has revolutionized therapy of metastatic renal cancer. The success of immunotherapy has renewed an interest to study these agents in adjuvant and neoadjuvant settings and prior to cytoreductive nephrectomy. This narrative review will give an overview of ongoing trials and early translational research outcomes. Recent findings In nonmetastatic renal cell carcinoma (RCC), five...