High diagnostic yield of splenic core biopsy in patients with pyrexia of unknown origin

A proportion of patients with pyrexia of unknown origin (PUO), or inflammation of unknown origin (IUO), are without a diagnosis following extensive clinical and laboratory evaluation.1-3 The outcome in this group of patients is variable; those with significant systemic inflammation may have prolonged hospital stays and a high mortality rate. Many have shown that the prognosis is dependent on the diagnosis, which is key to determining the...