Original paper
Reduced spontaneous itch in mouse models of cholestasis
Abstract
Pruritus is one of the most distressing symptoms in cholestatic patients. Plasma autotaxin (ATX) activity correlates with the severity of pruritus in cholestatic patients, but the pathophysiology is unclear. To study pruritus in mice, we measured scratch activity in cholestatic Atp8b1 mutant mice, a model for Progressive Familial Intrahepatic Cholestasis type 1, and wild type mice (WT) with alpha-naphthylisothiocyanate (ANIT)-induced...
Paper Details
Title
Reduced spontaneous itch in mouse models of cholestasis
Published Date
Mar 17, 2021
Journal
Volume
11
Issue
1
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Notes
History