Internal medicine

Phenotype

Tumor microenvironment

Female circumcision

Physiology

Bioinformatics

Biology

Gene

Cancer

Oncology

Cytotoxic T cell

In vitro

Immunology

Endometrial cancer

Adjuvant

Gynecology

Cancer research

Biochemistry

Hormone

Medicine

Immune system

Cancers

EC is the most common cancer in the female genital tract in developed countries, and with its increasing incidence due to risk factors, such as aging and obesity, tends to become a public health issue. Although EC is a hormone-dependent neoplasm, there are no recommendations for the determination of steroid hormone receptors in the tumor tissue and no hormone therapy has ever been assessed in the adjuvant setting. Furthermore, its immune environment has been slightly characterized, but recent evidences point out how EC microenvironment may increase self-tolerance by reducing the recruitment of cytotoxic immune cells to the tumor site and/or modifying their phenotype, making these cells no longer able to suppress tumor growth. Here we highlight insights for EC management from diagnosis to a desirable trend of personalized treatment.

New Insights into Endometrial Cancer