Chronic 2-photon imaging through a wearable PEDOT:PSS neurointerface

An ongoing effort in many neuroscience laboratories is to perform chronic optical imaging and multiplexed electrophysiological recordings in awake behaving mice. We have adapted the use of conformal thin parylene C in conjunction with conductive polymer PEDOT:PSS coating on the electrode sites to realize wearable microelectrode array devices with sufficient optical transparency to allow simultaneous multiphoton imaging and optogenetic...