Internal medicine

Immunotherapy

Pembrolizumab

Bladder cancer

Gastroenterology

Cancer

Urology

Surgery

Oncology

Neutropenia

Cystectomy

Neoadjuvant therapy

Chemotherapy

Cisplatin

Gemcitabine

Breast cancer

Medicine

Journal of Clinical Oncology

To evaluate the safety and efficacy of gemcitabine and cisplatin in combination with the immune checkpoint inhibitor pembrolizumab as neoadjuvant therapy before radical cystectomy (RC) in muscle-invasive bladder cancer.

Phase II Study of Gemcitabine and Split-Dose Cisplatin Plus Pembrolizumab as Neoadjuvant Therapy Before Radical Cystectomy in Patients With Muscle-Invasive Bladder Cancer