Internal medicine

Receptor

Organic chemistry

Combinatorial chemistry

EGFR inhibitors

Lead compound

Erlotinib

Epidermal growth factor receptor

Trastuzumab

ADME

Stereochemistry

Gene

Cancer

Mutant

Nursing

Medicinal chemistry

Chemistry

In vitro

T790M

Lapatinib

IC50

Morpholine

Adamantane

Gefitinib

Breast cancer

Docking (animal)

Biochemistry

Medicine

Bioorganic Chemistry

A new series of 1,3,4-thiadiazolo-adamantane derivatives were synthesized through molecular hybridization approach, then used as starting material to …

Development of adamantane scaffold containing 1,3,4-thiadiazole derivatives: Design, synthesis, anti-proliferative activity and molecular docking study targeting EGFR