Abstract LT019: The synaptic protein netrin G1 ligand (NGL-1) modulates the immunosuppressive environment in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest cancers, features a highly immunosuppressive environment, with expansion of cancer-associated fibroblasts (CAFs), and absence/inactivation of antitumor immune cells. Therefore, ways to manipulate this environment, favoring the antitumor cells, will be critical for effective therapies for PDAC. Recently, we identified the neuronal protein Netrin G1 Ligand (NGL-1) to be overexpressed in...