Original paper
Endothelin-1 drives invadopodia and interaction with mesothelial cells through ILK
Abstract
Cancer cells use actin-based membrane protrusions, invadopodia, to degrade stroma and invade. In serous ovarian cancer (SOC), the endothelin A receptor (ETAR) drives invadopodia by a not fully explored coordinated function of β-arrestin1 (β-arr1). Here, we report that β-arr1 links the integrin-linked kinase (ILK)/βPIX complex to activate Rac3 GTPase, acting as a central node in the adhesion-based extracellular matrix (ECM) sensing and...
Paper Details
Title
Endothelin-1 drives invadopodia and interaction with mesothelial cells through ILK
Published Date
Mar 1, 2021
Journal
Volume
34
Issue
9
Pages
108800 - 108800
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Notes
History