Pan-cancer chromatin analysis of the human vtRNA genes uncovers their association with cancer biology

Rafael Sebastián Fort; María Ana Duhagon

doi:https://doi.org/10.12688/f1000research.28510.2

doi.org/10.12688/f1000research.28510.2

Pan-cancer chromatin analysis of the human vtRNA genes uncovers their association with cancer biology

Rafael Sebastián Fort

,

Volume: 10, Pages: 182 - 182

Published: Jun 9, 2021

Abstract

Background: The vault RNAs (vtRNAs) are a class of 84-141-nt eukaryotic non-coding RNAs transcribed by RNA polymerase III, associated to the ribonucleoprotein complex known as vault particle. Of the four human vtRNA genes, vtRNA1-1, vtRNA1-2 and vtRNA1-3, clustered at locus 1, are integral components of the vault particle, while vtRNA2-1 is a more divergent homologue located in a second locus. Gene expression studies...

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Paper Details

Title

Pan-cancer chromatin analysis of the human vtRNA genes uncovers their association with cancer biology

DOI

doi.org/10.12688/f1000research.28510.2

Published Date

Jun 9, 2021

Journal

F1000Research

Volume

10

Pages

182 - 182

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