Catalysis

Boronic acid

Photochemistry

Metallurgy

Materials science

Coupling reaction

Coupling (piping)

Alkyl

Redox

Combinatorial chemistry

Organic chemistry

Mathematics

Photoredox catalysis

Mathematical analysis

Chemistry

Aryl

Photocatalysis

Dual role

Base (topology)

Nature Communications

The flourishing Ni/photoredox-catalyzed asymmetric couplings typically rely on redox-neutral reactions. In this work, we report a reductive cross-coupling of aryl iodides and α-chloroboranes under a dual catalytic regime to further enrich the metallaphotoredox chemistry. This approach proceeds under mild conditions (visible light, ambient temperature, no strong base) to access the versatile benzylic boronic esters with good functional group tolerance and excellent enantioselectivities.

Dual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters