Gene

Macroeconomics

Engineering

Ecology

Biotechnology

Bacteria

Biology

Bacillales

Polyhydroxyalkanoates

Economics

Biochemistry

Food science

Biochemical engineering

Genetics

Bacillus subtilis

Bioorganic chemistry

Bacillaceae

Biomass (ecology)

Agronomy

Microbiology

Enzyme

Chemistry

Metabolic engineering

Host (biology)

Heterologous

Production (economics)

Critical Reviews in Biotechnology

Bacillus subtilis is regarded as a suitable host for biochemical production owing to its excellent growth and bioresource utilization characteristics. In addition, the distinct endogenous metabolic pathways and the suitability of the heterologous pathways have made B. subtilis a robust and promising host for producing biochemicals, such as: bioalcohols; bioorganic acids (lactic acids, α-ketoglutaric acid, and γ-aminobutyric acid); biopolymers (poly(γ-glutamic acid, polyhydroxyalkanoates (PHA), and polysaccharides and monosaccharides (N-acetylglucosamine, xylooligosaccharides, and hyaluronic acid)); and bioflocculants. Also for producing oligopeptides and functional peptides, owing to its efficient protein secretion system. Several metabolic and genetic engineering techniques, such as target gene overexpression and inactivation of bypass pathways, have led to the improvement in production titers and product selectivity. In this review article, recent progress in the utilization of robust B. subtilis-based host systems for biomass conversion and biochemical production has been highlighted, and the prospects of such host systems are suggested.

<i>Bacillus subtilis</i> as a robust host for biochemical production utilizing biomass

Bacillus subtilis as a robust host for biochemical production utilizing biomass