Antepartum Depression and Preterm Birth: Pathophysiology, Epidemiology, and Disparities due to structural racism

Informed by the evidence of links between physiology of stress and parturition, we review recent epidemiologic evidence (2015–2020) of antenatal depression as a risk factor for preterm birth (PTB). We also explain racial/ethnic disparities in depression and preterm birth as a consequence of structural racism. Epidemiologic evidence is consistent in linking antepartum depression with an elevated risk of PTB. Antidepressant usage has been linked...