TRPV4 channels mediate the mechanoresponse in retinal microglia

The physiological and neurological correlates of plummeting brain osmolality during edema, traumatic CNS injury, and severe ischemia are compounded by neuroinflammation. Using multiple approaches, we investigated how retinal microglia respond to challenges mediated by increases in strain, osmotic gradients, and agonists of the stretch‐activated cation channel TRPV4. Dissociated and intact microglia were TRPV4‐immunoreactive and responded to the...