Original paper
Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice
Abstract
Inactivation of constitutive autophagy results in the formation of cytoplasmic inclusions in neurones, but the relationship between impaired autophagy and Lewy bodies (LBs) remains unknown. α-Synuclein and p62, components of LBs, are the defining characteristic of Parkinson's disease (PD). Until now, we have analyzed mice models and demonstrated p62 aggregates derived from an autophagic defect might serve as 'seeds' and can potentially be a...
Paper Details
Title
Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice
Published Date
Feb 25, 2021
Journal
Volume
30
Issue
6
Pages
443 - 453
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Notes
History