Adipose tissue estrogen production and metabolism in premenopausal women

Although the ovaries produce the majority of estrogens in women before menopause, estrogen is also synthesized in peripheral tissues such as adipose tissue (AT). The typical female AT distribution, concentrated in subcutaneous and femoro-gluteal regions, is estrogen-mediated, but the significance of estrogen synthesis in AT of premenopausal women is poorly understood. Serum and subcutaneous and visceral AT homogenates from 28 premenopausal women...