Review paper
Genetic disruption of zebrafish mab21l1 reveals a conserved role in eye development and affected pathways
Abstract
Background The male‐abnormal 21 like ( MAB21L ) genes are important in human ocular development. Homozygous loss of MAB21L1 leads to corneal dystrophy in all affected individuals along with cataracts and buphthalmos in some. The molecular function and downstream pathways of MAB21L factors are largely undefined. Results We generated the first mab21l1 zebrafish mutant carrying a putative loss‐of‐function allele, c.107delA p.(Lys36Argfs*7). At the...
Paper Details
Title
Genetic disruption of zebrafish mab21l1 reveals a conserved role in eye development and affected pathways
Published Date
Mar 12, 2021
Journal
Volume
250
Issue
8
Pages
1056 - 1073
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