Review paper
p53 and Tumor Suppression: It Takes a Network
Abstract
The TP53 tumor suppressor is the most frequently mutated gene in human cancer. p53 suppresses tumorigenesis by transcriptionally regulating a network of target genes that play roles in various cellular processes. Though originally characterized as a critical regulator for responses to acute DNA damage (activation of apoptosis and cell cycle arrest), recent studies have highlighted new pathways and transcriptional targets downstream of p53...
Paper Details
Title
p53 and Tumor Suppression: It Takes a Network
Published Date
Apr 1, 2021
Journal
Volume
31
Issue
4
Pages
298 - 310
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