Comparisons of fatigue between dialysis modalities: A cross-sectional study.

Published on Feb 10, 2021in PLOS ONE2.74
· DOI :10.1371/JOURNAL.PONE.0246890
Yukio Maruyama18
Estimated H-index: 18
(Jikei University School of Medicine),
Masaaki Nakayama41
Estimated H-index: 41
+ 2 AuthorsTakashi Yokoo28
Estimated H-index: 28
(Jikei University School of Medicine)
Sources
Abstract
Background Fatigue is one of the most frequent complications in dialyzed patients and is associated with poorer patient outcomes. Multiple factors are reported to be associated with fatigue development. Of them, the impacts of dialysis modalities remain unknown. Methods A total of 194 dialysis patients (mean age, 61±11 years; 134 males; modalities included hemodialysis (HD) in 26, online hemodiafiltration (HDF) in 74, peritoneal dialysis (PD) in 68, and combined therapy with PD and HD in 26 cases) were recruited for this cross-sectional study. Fatigue was assessed using the Profile of Mood States (POMS), a Visual Analogue Scale (VAS), and our original scale of fatigue, and depression was assessed by the Beck Depression Inventory-second edition (BDI-II). Our original scale of fatigue was administered both on dialysis and dialysis-free days to patients on HD and online HDF. Results The scores of the POMS, VAS, and our original scale were weakly but significantly inter-related (rho = 0.58, P<0.01; rho = 0.47, P<0.01, and rho = 0.42, P<0.01 between POMS and VAS, POMS and our original scale for fatigue, and VAS and our original scale for fatigue, respectively). The scores of these 3 tests showed no significant differences among the 4 modalities. On multivariate analysis, age, body mass index, creatinine, and employment status were associated with the presence or severity of fatigue, whereas dialysis modality was not. A similar result was obtained in 122 patients without depression. The prevalence of fatigue by our original scale was significantly lower on dialysis-free days than on dialysis days in patients on HD and online HDF. Conclusions The results suggest that there is no significant association between different dialysis modalities including HD, online HDF, PD and combined therapy with PD and HD and the prevalence or severity of fatigue.
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The annual survey of the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) was conducted for 4413 dialysis facilities at the end of 2017; among which 4360 facilities (98.8%) responded to the facility questionnaire, and 4188 (94.9%) responded to the patient questionnaire. The response rate of the 2017 survey was comparable with the past, even though it was the third year after the new anonymization method. The number of chronic dialysis patients in Japan continues to increase every...
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#1Tatsuya Suwabe (Mayo Clinic)H-Index: 21
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Background End-stage renal disease (ESRD) is related to high morbidity, mortality, and impaired health-related quality of life. While hemodialysis (HD) is the current life-saving standard of treatment for patients with ESRD, their quality of life (QoL) remains far from desirable. Online HDF (OL-HDF), due to its convenience, could improve the QoL of patients with ESRD, however, this remains uncertain. Objective We aimed to assess the body of evidence of OL-HDF compared to HD regarding QoL in pati...
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#1Andrew Davenport (Royal Free Hospital)H-Index: 79
#2Ayman Guirguis (University of Hertfordshire)H-Index: 5
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Introduction: Most patients take time to recover after a hemodialysis (HD) session. It has been suggested that recovery time is associated with intradialytic hypotension and rapid solute clearances. Other studies have reported a linkage to depression. We investigated the association between recovery time and intradialytic hypotension and depression. Methods: In five UK HD units, we screened for depressive symptoms using the Beck depression inventory-II, Patient Health Questionnaire, and recorded...
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#2Jun TangH-Index: 3
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Purpose The purpose of the study was to investigate the major factors affecting fatigue symptoms and to examine the relationships between fatigue symptoms and subjective and objective indicators in patients on hemodialysis (HD).
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Recent studies have revealed unique biological characteristics of molecular hydrogen (H2) as an anti-inflammatory agent. We developed a novel haemodialysis (E-HD) system delivering an H2 (30–80 ppb)-enriched dialysis solution by water electrolysis, and conducted a non-randomized, non-blinded, prospective observational study exploring its clinical impact. Prevalent chronic HD patients were allocated to either the E-HD (n = 161) group or the conventional HD (C-HD: n = 148) group, and received the ...
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#1Masaaki Nakayama (Fukushima Medical University)H-Index: 41
#2Noritomo Itami (Memorial Hospital of South Bend)H-Index: 21
Last. Sadayoshi Ito (Tohoku University)H-Index: 90
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Background and aim It is supposed that enhanced oxidative stress and inflammation are involved with the poor clinical outcomes in patients on chronic dialysis treatment. Recent studies have shown that molecular hydrogen (H2) is biologically active as an anti-inflammatory agent. Thus, we developed a novel hemodialysis (E-HD) system which delivers H2 (30 to 80 ppb)-enriched dialysis solution, to conduct a prospective observational study (UMIN000004857) in order to compare the long-term outcomes be...
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#1Luca Zazzeroni (UNIBO: University of Bologna)H-Index: 3
#2Gianandea Pasquinelli (UNIBO: University of Bologna)H-Index: 1
Last. Ivan Rubbi (UNIBO: University of Bologna)H-Index: 5
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BACKGROUND/AIMS: The increase in the survival rate of patients with chronic renal failure due to substitution treatment prompts an investigation of their quality of life (QoL), a key measure to evaluate the outcomes of chronic disease treatment. To determine whether hemodialysis or peritoneal dialysis provide a better QoL, a systematic meta-analysis was performed. METHODS: We searched through the database Cinahl, Medline, PubMed, Scopus and Proquest, including articles published from 2011 until ...
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#1Yu-Ling Bai (Chung Hwa University of Medical Technology)H-Index: 3
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Aims and objectives To investigate the fatigue levels and important fatigue predictors for patients undergoing haemodialysis. Background Fatigue is a common symptom for haemodialysis patients. With its debilitating and distressing effects, it impacts patients in terms of their quality of life while also increasing their mortality rate. Design A descriptive correlational study. Methods Convenience sampling was conducted at six chosen haemodialysis centres in Southern Taiwan. Data were collected v...
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#1Zbigniew NowakH-Index: 6
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Background It is a struggle to identify the most adaptive coping strategies with disease-mediated stress. Here, we hypothesize that intensity of coping strategies, including denial, in patients with end-stage renal disease (ESRD), varies with type of renal replacement therapy (RRT).
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