Design of polymers for siRNA delivery: Recent progress and challenges

RNA interference with the ability to specifically silence target genes has shown great potential to treat various diseases. The primary challenge for RNA interference is to effectively and selectively deliver genetic materials such as small interfering RNA (siRNA) to targeted tissues and cells in vivo . Numerous efforts have been made to overcome the extracellular and intracellular barriers during siRNA delivery. In this review, we focused on...