Anatomy

Internal medicine

Pathology

Hyaluronic acid

Central nervous system disease

Cartilage damage

Articular cartilage

Surgery

Physical therapy

Alternative medicine

Degenerative disease

Osteoarthritis

Knee replacement

Arthroplasty

Joint replacement

Knee Joint

Platelet-rich plasma

Intra articular

Medicine

Platelet

Journal of Functional Morphology and Kinesiology

Knee osteoarthritis (OA) is a chronic, degenerative, and progressive disease of articular cartilage, producing discomfort and physical disability in older adults. Thirteen percent of elderly people complain of knee OA. Management options for knee OA could be divided into the following categories: conservative, pharmacological, procedural, and surgical. Joint replacement is the gold standard, reserved for severe grades of knee OA, due to its complications rate and increased risk of joint revision. A nonsurgical approach is the first choice in the adult population with cartilage damage and knee OA. Yearly, more than 10% of knee OA-affected patients undergo intra-articular injections of different drugs, especially within three months after OA diagnosis. Several molecules, such as corticosteroids injection, hyaluronic acid (HA), and platelet-rich plasma (PRP), are managed to reduce the symptoms of patients with knee OA. The aim of this review was to offer an overview of intra-articular injections used for the treatment of OA and report the conventional pharmacological products used.

Intra-Articular Injections in Knee Osteoarthritis: A Review of Literature