α‐Synuclein evokes NLRP3 inflammasome‐mediated IL‐1β secretion from primary human microglia

GLIA6.20
Volume: 69, Issue: 6, Pages: 1413 - 1428
Published: Jan 28, 2021
Abstract
Synucleinopathies such as Parkinson's disease (PD) are hallmarked by α-synuclein (α-syn) pathology and neuroinflammation. This neuroinflammation involves activated microglia with increased secretion of interleukin-1β (IL-1β). The main driver of IL-1β secretion from microglia is the NLRP3 inflammasome. A critical link between microglial NLRP3 inflammasome activation and the progression of both α-syn pathology and dopaminergic neurodegeneration...
Paper Details
Title
α‐Synuclein evokes NLRP3 inflammasome‐mediated IL‐1β secretion from primary human microglia
Published Date
Jan 28, 2021
Journal
Volume
69
Issue
6
Pages
1413 - 1428
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