100th Anniversary of Macromolecular Science Viewpoint: User’s Guide to Supramolecular Peptide–Polymer Conjugates

Published on Jan 25, 2021in ACS Macro Letters6.903
· DOI :10.1021/ACSMACROLETT.0C00734
Julia Y. Rho6
Estimated H-index: 6
(Warw.: University of Warwick),
Sébastien Perrier69
Estimated H-index: 69
(Warw.: University of Warwick)
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Abstract
This Viewpoint highlights the design principles and development of peptide-based supramolecular polymers. Here we delve deep into the practicalities of synthesizing and characterizing these macromo...
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References100
Newest
#1Jie Yang (Warw.: University of Warwick)H-Index: 7
#2Ji-Inn Song (Warw.: University of Warwick)H-Index: 10
Last. Sébastien Perrier (Warw.: University of Warwick)H-Index: 69
view all 9 authors...
Typically, the morphologies of the self-assembled nanostructures from block copolymers are limited to spherical micelles, wormlike micelles and vesicles. Now, a new generation of materials with unique shape and structures, cylindrical soft matter particles (tubisomes), are obtained from the hierarchical self-assembly of cyclic peptide-bridged amphiphilic diblock copolymers. The capacity of obtained photo-responsive tubisomes as potential drug carriers is evaluated. The supramolecular tubisomes p...
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#1Franka V. Gruschwitz (FSU: University of Jena)H-Index: 4
#2Tobias Klein (FSU: University of Jena)H-Index: 6
Last. Johannes C. Brendel (FSU: University of Jena)H-Index: 19
view all 4 authors...
The field of supramolecular chemistry has long been known to generate complex materials of different sizes and shapes via the self-assembly of single or multiple low molecular weight building blocks. Matching the complexity found in natural assemblies, however, remains a long-term challenge considering its precision in organizing large macromolecules into well-defined nanostructures. Nevertheless, the increasing understanding of supramolecular chemis-try has paved the way to several attempts in ...
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#1Jie Chen (SWUST: Southwest University of Science and Technology)H-Index: 1
#2Qiang Li (SWUST: Southwest University of Science and Technology)H-Index: 2
Last. Liang‐Chun Li (SWUST: Southwest University of Science and Technology)H-Index: 7
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: Self-assembling peptides can be used to design new materials for medical and biological applications. Here we synthesized and characterized two novel cyclic γ-peptides (γ-CPs) with hydrophobic inner surfaces. The NMR and FT-IR studies confirmed that the CPs could self-assemble into parallel stacking structures via intermolecular H-bonds and π-π interactions. The morphologies of the self-assembly CPs showed bundles of nanotubes via transmission electron microscopy (TEM); these nanotubes form wa...
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#1Matthias Hartlieb (University of Potsdam)H-Index: 23
#2Edward D. H. Mansfield (Warw.: University of Warwick)H-Index: 10
Last. Sébastien Perrier (Warw.: University of Warwick)H-Index: 69
view all 3 authors...
Supramolecular polymers or fibers are non-covalent assemblies of unimeric building blocks connected by secondary interactions such as hydrogen bonds or π-π interactions. Such structures hold enormous potential in the development of future materials, as their non-covalent nature makes them highly modular and adaptive. Within this review we aim to provide a broad overview over the area of linear supramolecular polymers including the different mechanism of their polymerization as well as methods es...
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#1Julia Y. Rho (Warw.: University of Warwick)H-Index: 6
#2Henry Cox (University of Manchester)H-Index: 8
Last. Sébastien Perrier (Warw.: University of Warwick)H-Index: 69
view all 9 authors...
Self-assembling peptides have the ability to spontaneously aggregate into large ordered structures. The reversibility of the peptide hydrogen bonded supramolecular assembly make them tunable to a host of different applications, although it leaves them highly dynamic and prone to disassembly at the low concentration needed for biological applications. Here we demonstrate that a secondary hydrophobic interaction, near the peptide core, can stabilise the highly dynamic peptide bonds, without losing...
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#1Qiao Song (Warw.: University of Warwick)H-Index: 13
#2Jie Yang (Warw.: University of Warwick)H-Index: 7
Last. Sébastien Perrier (Warw.: University of Warwick)H-Index: 69
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Cyclic peptide–polymer conjugates are capable of self-assembling into supramolecular polymeric nanotubes driven by the strong multiple hydrogen bonding interactions between the cyclic peptides. In this study, we have engineered responsive nanotubes by introducing a cleavable bond that responds to a reductant utilizing pyridyl disulfide reaction chemistry. Reactions between a cysteine containing cyclic peptide (CP-SH) and pyridyl disulfide containing polymers were initially studied, leading to th...
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#1Ronja Otter (University of Mainz)H-Index: 7
#2Pol Besenius (University of Mainz)H-Index: 24
The following review gives an overview about synthetic peptide–polymer conjugates as macromolecular building blocks and their self-assembly into a variety of supramolecular architectures, from supramolecular polymer chains, to anisotropic 1D arrays, 2D layers, and more complex 3D networks. A selection of recent literature examples using linear, coiled-coil and cyclic peptide motifs is provided. The reversible nature of the unimer-to-supramolecular polymer transition provides unique opportunities...
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#1Matthias Hartlieb (Warw.: University of Warwick)H-Index: 23
#2Sylvain Catrouillet (Warw.: University of Warwick)H-Index: 10
Last. Sébastien Perrier (Warw.: University of Warwick)H-Index: 69
view all 6 authors...
Cyclic peptide nanotubes (CPNT) consisting of an even number of amino acids with an alternating chirality are highly interesting materials in a biomedical context due to their ability to insert themselves into cellular membranes. However, unwanted unspecific interactions between CPNT and non-targeted cell membranes are a major drawback. To solve this issue we have synthetized a series of CPNT–polymer conjugates with a cleavable covalent connection between macromolecule and peptide. As a result, ...
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#1Qiao Song (Warw.: University of Warwick)H-Index: 13
#2Jie Yang (Warw.: University of Warwick)H-Index: 7
Last. Sébastien Perrier (Warw.: University of Warwick)H-Index: 69
view all 4 authors...
A supramolecular strategy of switching the self-assembly of cyclic peptide–polymer conjugates using host–guest chemistry is proposed. The formation of tubular supramolecular polymers based on cyclic peptide–polymer conjugates can be controlled by reversibly attaching cucurbit[7]uril onto the cyclic peptide via host–guest interactions.
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#1Johannes C. Brendel (Warw.: University of Warwick)H-Index: 19
#2Joaquin Sanchis (Monash University)H-Index: 19
Last. Sébastien Perrier (Warw.: University of Warwick)H-Index: 69
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The properties and structures of viruses are directly related to the three‐dimensional structure of their capsid proteins, which arises from a combination of hydrophobic and supramolecular interactions, such as hydrogen bonds. The design of synthetic materials demonstrating similar synergistic interactions still remains a challenge. Herein, we report the synthesis of a polymer/cyclic peptide conjugate that combines the capability to form supramolecular nanotubes via hydrogen bonds with the prope...
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Cited By3
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#1Qiao Song (Southern University of Science and Technology)H-Index: 13
#2Andrew Kerr (Warw.: University of Warwick)H-Index: 6
Last. Sébastien Perrier (Warw.: University of Warwick)H-Index: 69
view all 5 authors...
Supramolecular copolymers are an emerging class of materials, which bring together different properties and functionalities of multiple components via noncovalent interactions. While it is widely acknowledged that the repeating unit sequence plays an essential role on the performance of these materials, mastering and tuning the supramolecular copolymer sequence is still an open challenge. To date, only statistical supramolecular copolymers have been reported using cyclic peptide–polymer conjugat...
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#1Federica Novelli (University of Santiago de Compostela)H-Index: 1
#2Marcos Vilela (University of Santiago de Compostela)
Last. Juan R. Granja (University of Santiago de Compostela)H-Index: 37
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Light-induced molecular piping of cyclic peptide nanotubes to form bent tubular structures is described. The process is based on the [4+4] photocycloaddition of anthracene moieties, whose structural changes derived from the interdigitated flat disposition of precursors to the corresponding cycloadduct moieties, induced the geometrical modifications in nanotubes packing that provokes their curvature. For this purpose, we designed a new class of cyclic peptide nanotubes formed by β- and α-amino ac...
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