Glaucoma is considered a chronic disease that requires lifelong management. Chronic diseases are known to be highly associated with psychological disturbances such as depression and anxiety. There have also been many studies on association between anxiety or depression and glaucoma. The majority of these studies explained that the glaucoma diagnosis causes anxiety or depression. However, It is also necessary to evaluate whether the psychological disturbance itself affect glaucoma. Therefore, we investigated the association of anxiety and depression with glaucoma progression, and elucidate mechanisms underlying that. We included 251 eyes with open angle glaucoma who were followed up for at least 2 years in this retrospective case-control study. The Beck Anxiety Inventory (BAI) and Beck Depressive Inventory-II (BDI-II) were used to assess anxiety and depression in glaucoma patients. Patients were classified into groups (high-anxiety group; HA-G, low-anxiety group; LA-G, high-depression group; HD-G, low-depression group; LD-G) according to their score on the BAI or BDI-II (separately). In logistic regression analysis, disc hemorrhage, peak intraocular pressure (IOP) and RNFL thickness loss rate were significantly associated with high anxiety (p = 0.017, p = 0.046, p = 0.026). RNFL thinning rate and disc hemorrhage were significant factors associated with anxiety in multivariate models (p = 0.015, p = 0.019). Multivariate linear regression analysis showed a significant positive correlation between the rate of RNFL thickness loss and BAI score (B = 0.058; 95% confidential interval = 0.020-0.097; p = 0.003), and RNFL loss and IOP fluctuation (B = 0.092; 95% confidential interval = 0.030-0.154; p = 0.004). For the depression scale, visual field mean deviation and heart rate variability were significantly associated with high depression in multivariate logistic regression analysis (p = 0.003, p = 0.006). We suggest that anxiety increase the risk of glaucoma progression and they are also associated with IOP profile and disc hemorrhage.
Abstract Purpose To investigate if a stress event can influence intraocular pressure (IOP) in a group of healthy individuals. Design Case-control study. Participants A total of 28 healthy subjects were included: 17 in the stress group and 11 in the control group. Methods The Trier Social Stress Test (TSST) is a tool to evaluate cortisol response to psychological stimulation based on the stress induced by public speaking. All participants underwent a modified diurnal tension curve (DTC) 1 week be...
Aims To assess the impact of anxiety and depression in the risk of converting to glaucoma in a cohort of glaucoma suspects followed over time. Methods The study included a retrospective cohort of subjects with diagnosis of glaucoma suspect at baseline, extracted from the Duke Glaucoma Registry. The presence of anxiety and depression was defined based on electronic health records billing codes, medical history and problem list. Univariable and multivariable Cox proportional hazards models were us...
Abstract We examined the intraocular pressure responsiveness to oral examination stress, as well as the mediating role of the perceived levels of public speaking anxiety on intraocular pressure changes. Thirty-two university students (intervention group) publicly defended their degree final project, and intraocular pressure and perceived levels of stress were measured before and after the oral presentation, and after 10 min of recovery. The control group (n = 32) was not exposed to any stressful...
#1Da Young Shin(Catholic University of Korea)H-Index: 3
#2Soo Ji Jeon(Catholic University of Korea)H-Index: 7
Last. Chan Kee Park(Catholic University of Korea)H-Index: 27
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In meta-analyses, it has been reported that myopia is a risk factor for glaucoma and there is increasing evidence that autonomic dysfunction causing vascular dysregulation or perfusion dysfunction is considered an important factor in the progression of glaucoma. There have been experimental studies to find out the association between autonomic nervous system and ocular growth, but no clinical study yet has evaluated the relationship between them. Therefore, we enrolled 208 open angle glaucoma pa...
#1Da Young Shin(Catholic University of Korea)H-Index: 3
#2Soo Ji Jeon(Catholic University of Korea)H-Index: 7
Last. Chan Kee Park(Catholic University of Korea)H-Index: 27
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Peripapillary vessel density, which is reduced in eyes with glaucoma, has been proposed as a diagnostic tool for the desease and peripapillary choroidal microvasculature dropout(MvD) is considered one of pathophysiological manifestation of glaucomatous damage. However, little is known about the underlying pathogenic mechanism of dropout. According to recent studies, MvD is associated with structural changes in ONH structures. Therefore, we investigated the association between peripapillary scler...
Last. Magnus Simrén(UNC: University of North Carolina at Chapel Hill)H-Index: 78
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BACKGROUND: Anxiety or depression, in other words, psychological distress, are common comorbidities in patients with irritable bowel syndrome (IBS), but their interaction with pathophysiological factors and other symptoms are unclear. METHODS: Patients with IBS (Rome III criteria), thoroughly characterized regarding pathophysiology (colonic transit time, visceral sensitivity, and autonomic nervous system [ANS] function), symptom profile (IBS severity, somatic symptoms, gastrointestinal [GI]-spec...
: Autonomic dysfunction is a feature of glaucoma patients, which are reported to be related to glaucoma progression. We investigated pupil responses to a light flash using dynamic pupillometry in glaucoma patients to assess autonomic nervous system status. In total, 97 glaucoma patients, including 21 eyes of 21 glaucoma patients with cardiac autonomic dysfunction, were enrolled. Pupil reactions were assessed using 1 flash of white light after 2 minutes of dark adaptation and recorded using dynam...
Last. Carl Foster(UWL: University of Wisconsin–La Crosse)H-Index: 84
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Cycling is a sport which requires great physical effort from athletes. The stress and anxiety of competition might interfere greatly with performance, by impacting the autonomic system. Physiological alterations, such as situations that irritate, frighten or excite the individual can cause a stress response, defined as a response of the organism to reestablish the homeostasis, regardless of its relationship to a sports situation. The aim of this study was to present data on the autonomic changes...
Background To investigate the prevalence of depression and anxiety among subjects with self-reported glaucoma and the association between self-reported glaucoma and depression respectively anxiety in a European cohort.
#1Xinbo Zhang(OHSU: Oregon Health & Science University)H-Index: 24
#2Anna Dastiridou(UCLA: University of California, Los Angeles)H-Index: 14
Last. David Huang(OHSU: Oregon Health & Science University)H-Index: 93
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Purpose To compare longitudinal glaucoma progression detection using optical coherence tomography (OCT) and visual field (VF). Design Validity assessment. Methods We analyzed subjects with more than 4 semi-annual follow-up visits (every 6 months) in the multicenter Advanced Imaging for Glaucoma Study. Fourier-domain optical coherence tomography (OCT) was used to map the thickness of the peripapillary retinal nerve fiber layer (NFL) and ganglion cell complex (GCC). OCT-based progression detection...
Background null Glaucoma is the second most-common blinding ophthalmic disease in the world, and its incidence has been rising year by year in recent years. Currently, the main treatment of glaucoma still relies on surgery. Glaucoma patients often suffer from various psychological problems like anxiety and depression not only because of the lack of understanding of the surgical treatment of glaucoma, but also the long-term stress and the poor prognosis. As alternative therapies, non-pharmacologi...
#2Dimitrios Kazantzis(UoA: National and Kapodistrian University of Athens)H-Index: 3
Last. Irini Chatziralli(UoA: National and Kapodistrian University of Athens)H-Index: 21
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Purpose: The purpose of this review was to evaluate the association between glaucoma and depression and to identify possible risk factors for depressive symptoms in glaucoma patients.Methods: A total of 587 abstracts were screened and 32 studies were deemed eligible for inclusion in this review.Results: An association of glaucoma and depression was found, while advanced disease stage, older age, female sex and faster visual loss progression were recognized as potential risk factors for depressio...
