<b><i>Objective:</i></b> This randomized controlled trial aims to verify the efficacy of a combined fractional CO<sub>2</sub> laser and rhodamine-intense pulsed-light (r-IPL) protocol in the photoaging therapy. <b><i>Background:</i></b> Skin aging is related to multiple environmental and genetic factors that give rise to different manifestations. In recent years many techniques have been proposed for the rejuvenation of the skin of the face such as ablative and nonablative procedures. Combination of laser or light sources with different wavelengths represents a safe and effective treatment method. r-IPL is a new pulsed-light technique capable to generate wavelengths varying from 550 to 650 nm proposed in nonablative photorejuvenation with a good efficacy and safety profile. <b><i>Methods:</i></b> Twenty-two patients (skin phototypes II-III, aged 46-67 years) were randomly allocated into two groups: group A was treated only with a therapeutic standard dose of the fractional CO<sub>2</sub> laser, whereas group B was treated with a combined therapy of r-IPL and fractional CO<sub>2</sub> laser. All patients were treated up to three times at a 2-month interval. Efficacy of the procedures was assessed thanks to the Fitzpatrick Wrinkle Severity Scale (scores 1-9) before treatment and at a 4-month follow-up from the last treatment. <b><i>Results:</i></b> Patients treated with the combination of r-IPL and fractional CO<sub>2</sub> laser showed better results in terms of wrinkle reduction according to the Fitzpatrick Wrinkle Severity score (2.82 ± 0.87 vs. 3.09 ± 1.14), with a statistically significant reduction in healing times (7.82 ± 0.75 vs. 13.82 ± 1.94 days, <i>p</i> ≤ 0.001) and duration of post-treatment erythema (3.55 ± 0.93 vs. 8.18 ± 1.47 days, <i>p</i> ≤ 0.001). Patient satisfaction was higher after combined fractional CO<sub>2</sub> laser and r-IPL treatment. <b><i>Conclusions:</i></b> Our data suggest that combined use of fractional CO<sub>2</sub> laser and r-IPL may lead to excellent results in terms of skin...