Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells

Cancer therapy is often hampered by the disease’s development of resistance to anticancer drugs. We previously showed that the autonomously upregulated product of fibroblast growth factor 13 gene ( FGF13 ; also known as FGF homologous factor 2 ( FHF2 )) is responsible for the cisplatin resistance of HeLa cisR cells and that it is likely responsible for the poor prognosis of cervical cancer patients treated with cisplatin. Here we show that...