Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis

Radiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown.The objective of the study is to provide an estimated RIS prevalence in a population-based cohort of children.We used data from the Generation R study to identify the childhood RIS prevalence.In 5238 participants, only one RIS case was identified (prevalence:...