Gene

Amyotrophic lateral sclerosis

Neuroscience

Biology

Virology

Immunology

Genetics

Bioinformatics

Genome

Central nervous system

Endogeny

Internal medicine

Endogenous retrovirus

Multiple sclerosis

Medicine

Disease

Pathogenesis

Nervous system

Pathology

Pharmaceuticals

Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. The toxicity of HERV-derived RNAs and proteins for neuronal cells has been demonstrated. The involvement of HERV in the pathogenesis of currently incurable diseases might offer new treatment strategies based on the inhibition of HERV activities by small molecules or therapeutic antibodies.

Endogenous Retroviruses in Nervous System Disorders