Papers 1138
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#1Ashli M. Heustess (Campbell University)
#2Melissa A. Allard (Campbell University)
Last. Pius S. Fasinu (Campbell University)H-Index: 14
view all 4 authors...
Since the outbreak and subsequent declaration of COVID-19 as a global pandemic in March 2020, concerted efforts have been applied by the scientific community to curtail the spread of the disease and find a cure. While vaccines constitute a vital part of the public health strategy to reduce the burden of COVID-19, the management of this disease will continue to rely heavily on pharmacotherapy. This study aims to provide an updated review of pharmacological agents that have been developed and/or r...
#1Astrid Rivera-Antonio (IPN: Instituto Politécnico Nacional)
#2Martha Cecilia Rosales-Hernández (IPN: Instituto Politécnico Nacional)H-Index: 13
Last. Itzia I. Padilla-Martínez (IPN: Instituto Politécnico Nacional)H-Index: 15
view all 9 authors...
Myeloperoxidase (MPO) is an enzyme present in human neutrophils, whose main role is to provide defenses against invading pathogens. However, highly reactive oxygen species (ROS), such as HOCl, are generated from MPO activity, leading to chronic diseases. Herein, we report the microwave-assisted synthesis of a new series of stable (E)-(2-hydroxy)-α-aminocinnamic acids, in good yields, which are structurally analogous to the natural products (Z)-2-hydroxycinnamic acids. The radical scavenging acti...
#1Nicole Moschny (MHH: Hannover Medical School)H-Index: 3
#2Gudrun HefnerH-Index: 11
Last. Catharina Meissner (MHH: Hannover Medical School)
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Both inflammation and smoking can influence a drug’s pharmacokinetic properties, i.e., its liberation, absorption, distribution, metabolism, and elimination. Depending on, e.g., pharmacogenetics, these changes may alter treatment response or cause serious adverse drug reactions and are thus of clinical relevance. Antipsychotic drugs, used in the treatment of psychosis and schizophrenia, should be closely monitored due to multiple factors (e.g., the narrow therapeutic window of certain psychotrop...
#1Joseph M Blondeau (Royal University Hospital)H-Index: 13
#2Heleen H DeCory (UR: University of Rochester)H-Index: 10
Background: Besifloxacin ophthalmic suspension 0.6% (w/v%) contains benzalkonium chloride (BAK) as a preservative. We evaluated the in vitro time-kill activity of besifloxacin, alone and in combination with BAK, against common bacteria implicated in ophthalmic infections. Methods: The activity of besifloxacin (100 µg/mL), BAK (10, 15, 20, and 100 µg/mL), and combinations of besifloxacin and BAK were evaluated against isolates of Staphylococcus epidermidis (n = 4), Staphylococcus aureus (n = 3), ...
#1Seung-Joo Yang (Gwangju Institute of Science and Technology)H-Index: 4
#2Seung-Je Jeon (Gwangju Institute of Science and Technology)H-Index: 1
Last. Chul-Seung Park (Gwangju Institute of Science and Technology)H-Index: 26
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Cereblon (CRBN), a primary target of immune-modulatory imide drugs (IMiDs), functions as a substrate receptor in the CUL4-RBX1-DDB1-CRBN (known as CRL4CRBN) E3 ubiquitin ligase complex. Binding of IMiDs to CRBN redirects the CRL4CRBN E3 ubiquitin ligase to recruit or displace its substrates. Interaction between CRBN and the AMPK α subunit leads to CRL4CRBN-dependent degradation of the γ subunit and inhibits AMPK activity. However, the effect of thalidomide on the function of CRBN as a negative r...
#1Abeer A. Ibrahim (Sulaimani Polytechnic University)
#2Mohanad Mousa Kareem (University of Babylon)H-Index: 3
Last. Usama I. Sahib (University of Technology, Iraq)H-Index: 5
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In this study, a platinum(II) complex ([Pt(H2L)(PPh3)] complex) containing a thiocarbohydrazone as the ligand was tested as an anti-proliferative agent against ovarian adenocarcinoma (Caov-3) and human colorectal adenocarcinoma (HT-29) through MTT assays. Apoptotic markers were tested by the AO/PI double staining assay and DNA fragmentation test. Flow cytometry was conducted to measure cell cycle distribution, while the p53 and caspase-8 pathways were tested via immunofluorescence assay. Results...
#1Ana Reis-Mendes (University of Porto)H-Index: 3
#2José Luís Dores-Sousa (University of Porto)H-Index: 6
Last. Vera Marisa Costa (University of Porto)H-Index: 26
view all 12 authors...
Mitoxantrone (MTX) is a pharmaceutical drug used in the treatment of several cancers and refractory multiple sclerosis (MS). Despite its therapeutic value, adverse effects may be severe, namely the frequently reported cardiotoxicity, whose mechanisms need further research. This work aimed to assess if inflammation or oxidative stress-related pathways participate in the cardiotoxicity of MTX, using the mouse as an animal model, at two different age periods (infant or adult mice) using two therape...
#1Daan V. Bunt (UG: University of Groningen)
#2Adriaan J. Minnaard (UG: University of Groningen)H-Index: 74
Last. Sahar El Aidy (UG: University of Groningen)H-Index: 25
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A disturbed interaction between the gut microbiota and the mucosal immune system plays a pivotal role in the development of inflammatory bowel disease (IBD). Various compounds that are produced by the gut microbiota, from its metabolism of diverse dietary sources, have been found to possess anti-inflammatory and anti-oxidative properties in in vitro and in vivo models relevant to IBD. These gut microbiota-derived metabolites may have similar, or more potent gut homeostasis-promoting effects comp...
#1Sherif A. El-Kafrawy (KAU: King Abdulaziz University)H-Index: 13
#2Aymn T. Abbas (KAU: King Abdulaziz University)H-Index: 8
Last. Esam I. Azhar (KAU: King Abdulaziz University)H-Index: 35
view all 8 authors...
Identified in 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and often fatal acute respiratory illness in humans. No approved prophylactic or therapeutic interventions are currently available. In this study, we developed chicken egg yolk antibodies (IgY Abs) specific to the MERS-CoV spike (S) protein and evaluated their neutralizing efficiency against MERS-CoV infection. S-specific IgY Abs were produced by injecting chickens with the purified recombinant S protei...
#1Mei-Hwa Lee (ISU: I-Shou University)H-Index: 14
#2James L. Thomas (UNM: University of New Mexico)H-Index: 26
Last. Hung-Yin Lin (NUK: National University of Kaohsiung)H-Index: 19
view all 6 authors...
Programmed death-ligand 1 protein (PD-L1) has been posited to have a major role in suppressing the immune system during pregnancy, tissue allografts, autoimmune disease and other diseases, such as hepatitis. Photodynamic therapy uses light and a photosensitizer to generate singlet oxygen, which causes cell death (phototoxicity). In this work, photosensitizers (such as merocyanine) were immobilized on the surface of magnetic nanoparticles. One peptide sequence from PD-L1 was used as the template ...
Top fields of study
Cancer research