Broad spectrum

Catalysis

Bacteria

Biology

Materials science

Reactive oxygen species

Sterilization (economics)

Economics

Biochemistry

Peroxidase

Foreign exchange market

Point of delivery

Genetics

Combinatorial chemistry

Nanotechnology

Monetary economics

Agronomy

Microbiology

Pathogenic bacteria

Enzyme

Radical

Chemistry

Foreign exchange

Advanced Materials

Besides the pandemic caused by the coronavirus outbreak, many other pathogenic microbes also pose a devastating threat to human health, for instance, pathogenic bacteria. Due to the lack of broad‐spectrum antibiotics, it is urgent to develop nonantibiotic strategies to fight bacteria. Herein, inspired by the localized “capture and killing” action of bacteriophages, a virus‐like peroxidase‐mimic (V‐POD‐M) is synthesized for efficient bacterial capture (mesoporous spiky structures) and synergistic catalytic sterilization (metal–organic‐framework‐derived catalytic core). Experimental and theoretical calculations show that the active compound, MoO 3 , can serve as a peroxo‐complex‐intermediate to reduce the free energy for catalyzing H 2 O 2 , which mainly benefits the generation of •OH radicals. The unique virus‐like spikes endow the V‐POD‐M with fast bacterial capture and killing abilities (nearly 100% at 16 µg mL –1 ). Furthermore, the in vivo experiments show that V‐POD‐M possesses similar disinfection treatment and wound skin recovery efficiencies to vancomycin. It is suggested that this inexpensive, durable, and highly reactive oxygen species (ROS) catalytic active V‐POD‐M provides a promising broad‐spectrum therapy for nonantibiotic disinfection.

Bioinspired Spiky Peroxidase‐Mimics for Localized Bacterial Capture and Synergistic Catalytic Sterilization