Minimal genome-wide human CRISPR-Cas9 library

Volume: 22, Issue: 1
Published: Jan 21, 2021
CRISPR guide RNA libraries have been iteratively improved to provide increasingly efficient reagents, although their large size is a barrier for many applications. We design an optimised minimal genome-wide human CRISPR-Cas9 library (MinLibCas9) by mining existing large-scale gene loss-of-function datasets, resulting in a greater than 42% reduction in size compared to other CRISPR-Cas9 libraries while preserving assay sensitivity and...
Paper Details
Minimal genome-wide human CRISPR-Cas9 library
Published Date
Jan 21, 2021
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