Effects of genetic background, sex, and age on murine atrial electrophysiology
Abstract
Genetically altered mice are powerful models to investigate mechanisms of atrial arrhythmias, but normal ranges for murine atrial electrophysiology have not been robustly characterized.We analyzed results from 221 electrophysiological (EP) studies in isolated, Langendorff-perfused hearts of wildtype mice (114 female, 107 male) from 2.5 to 17.7 months (mean 7 months) with different genetic backgrounds (C57BL/6, FVB/N, MF1, 129/Sv, Swiss agouti)....
Paper Details
Title
Effects of genetic background, sex, and age on murine atrial electrophysiology
Published Date
Jan 19, 2021
Journal
Volume
23
Issue
6
Pages
958 - 969
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