Original paper
Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation
Abstract
Tissue resident mast cells (MCs) rapidly initiate neutrophil infiltration upon inflammatory insult, yet the molecular mechanism is still unknown. Here, we demonstrated that MC-derived tumor necrosis factor (TNF) was crucial for neutrophil extravasation to sites of contact hypersensitivity-induced skin inflammation by promoting intraluminal crawling. MC-derived TNF directly primed circulating neutrophils via TNF receptor-1 (TNFR1) while being...
Paper Details
Title
Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation
Published Date
Mar 1, 2021
Journal
Volume
54
Issue
3
Pages
468 - 483.e5
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Notes
History