Cancer Cell Detection on the Surface of Top-Gated Monolayer Graphene via Raman Spectroscopy

A label-free biosensor is described based on the Raman spectroscopic signatures of monolayer graphene, which are modified in the compartment of cancer cells because of electron-phonon coupling in monolayer graphene. Specifically, the Raman spectra of electrostatically gated monolayer graphene on SiO2/Si substrates, in the voltage range from 0 to 5 V, were studied in the absence and the presence of cancer cells. Density functional theory...