Short review of SEC, a potential dexamethasone-sparing regimen for glioblastoma: Spironolactone, ecallantide, clotrimazole

• Brain edema is a common problem during the course of glioblastoma. • Brain edema often requires treatment on its own, separate from specific anti-tumor treatments. • Current first-line treatment is dexamethasone or a related corticosteroid. • Use of dexamethasone or related corticosteroid shortens survival. • Three old drugs - the diuretic spironolactone, the anti-bradykinin drug ecallantide, and the antifungal drug clotrimazole each have...