Topological Data Analysis of Coronary Plaques Demonstrates the Natural History of Coronary Atherosclerosis

This study sought to identify distinct patient groups and their association with outcome based on the patient similarity network using quantitative coronary plaque characteristics from coronary computed tomography angiography (CTA). Coronary CTA can noninvasively assess coronary plaques quantitatively. Patients who underwent 2 coronary CTAs at a minimum of 24 months’ interval were analyzed (n = 1,264). A similarity Mapper network of patients was...