With the introduction of performance-based earthquake engineering (PBEE), engineers have strived to relate building performance to different seismic hazard levels. Expected annual loss (EAL) and collapse safety described by mean annual frequency of collapse (MAFC) have become employed more frequently, but tend to be limited to seismic assessment rather than design. This article outlines an integrated performance-based seismic design (IPBSD) method that uses EAL and MAFC as design parameters. With these, as opposed to conventional intensity-based strength and/or drift requirements, IPBSD limits expected monetary losses and maintains a sufficient and quantifiable level of collapse safety in buildings. Through simple procedures, it directly identifies feasible structural solutions without the need for detailed calculations and numerical analysis. This article outlines its implementation alongside other contemporary risk-targeted and code-based approaches. Several case study reinforced concrete frame structures are evaluated using these approaches and the results appraised via verification analysis. The agreement and consistency of the design solutions and the intended targets are evaluated to demonstrate the suitability of each method. The proposed framework is viewed as a stepping stone for seismic design with advanced performance objectives in line with modern PBEE requirements.