Immunoglobulin G4–related disease of the paratestis: Can we avoid radical treatment?:

Published on Dec 27, 2020in Journal of Clinical Urology
· DOI :10.1177/2051415820982778
Thomas Thompson2
Estimated H-index: 2
(University of Manchester),
Thomas Brophy (University of Manchester)+ 2 AuthorsRichard Napier-Hemy (University of Manchester)
#1Kunio Mochizuki (University of Yamanashi)H-Index: 18
#2Yuki Hanai (University of Yamanashi)H-Index: 1
Last. Tetsuo Kondo (University of Yamanashi)H-Index: 26
view all 8 authors...
: IgG4-related disease (IgG4-RD) can affect various organs, and the pancreas and salivary gland are representative examples. We report a rare case of IgG4-RD of the paratestis. A 74-year-old man presented with left scrotal swelling. Scrotopuncture drainage and cytology confirmed a clear, yellow retention liquid (130 mL) with many small, similar lymphocytes and a few plasmacytes. Many lymphoid cells were immunopositive for CD3 on a cell block section, indicating that a predominant type of lymphoi...
1 CitationsSource
#1Luis Daniel Carrillo-Córdova (HGM: Hospital General de México)H-Index: 1
#2Carlos Alberto Carrillo-Córdova (HGM: Hospital General de México)H-Index: 1
Last. Raúl Carrillo-EsperH-Index: 9
view all 6 authors...
: La enfermedad relacionada con la inmunoglobulina G4 (ER-IgG4) es una enfermedad fibroinflamatoria de etiologia desconocida, la cual se caracteriza por presentar lesiones en forma de tumoraciones, concentraciones sericas aumentadas de IgG4 y celulas plasmaticas con una infiltracion importante de IgG4, junto con flebitis obliterante y fibrosis. Esta enfermedad suele tener afeccion multiorganica, incluyendo el pancreas, el tracto biliar, las glandulas salivares, los tejidos periorbitarios, los ri...
4 CitationsSource
#1Zachary S. Wallace (Harvard University)H-Index: 25
#2Vikram Deshpande (Harvard University)H-Index: 100
Last. John H. Stone (Harvard University)H-Index: 76
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Objective IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition that can affect nearly any organ. Prior studies have focused on individual cases of IgG4-RD or small case series. This study was undertaken to report detailed clinical and laboratory findings in a larger group of patients with IgG4-RD whose diagnosis was established by strict clinicopathologic correlation. Methods The baseline features of 125 patients with biopsy-proven IgG4-RD were reviewed. The diagnosis...
265 CitationsSource
#1Motohisa Yamamoto (Sapporo Medical University)H-Index: 35
#2Hidetaka Yajima (Sapporo Medical University)H-Index: 11
Last. Yasuhisa Shinomura (Sapporo Medical University)H-Index: 66
view all 21 authors...
AbstractObjective. Immunoglobulin (Ig)G4-related disease (IgG4-RD) is a new disease entity that has only been identified this century. Clinical information is thus lacking. We established the Sapporo Medical University and Related Institutes Database for Investigation and Best Treatments of IgG4-related Disease (SMART) to clarify the clinical features of IgG4-RD and provide useful information for clinicians.Methods. Participants comprised 122 patients with IgG4-related dacryoadenitis and/or sial...
69 CitationsSource
#1Takashi KarashimaH-Index: 22
#2Yoshinori TaniguchiH-Index: 18
Last. Taro ShuinH-Index: 49
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Background We report a case of a 33-year-old man who presented with immunoglobulin (Ig)G4-related disease (IgG4-RD) forming a pseudotumor in the left paratesticular region during oral administration of corticosteroid for Wells syndrome, which involves cellulitis with eosinophilia.
10 CitationsSource
Introduction Paratesticular fibrous pseudotumors represent benign new growths confined to intrascrotal structures. Both pathogenesis and clinical management are little understood due to the rarity of the lesion, with less than 200 cases reported to date. Recently, paratesticular fibrous pseudotumors have been postulated to be immunoglobulin G4-related, pathogenetically. Here we report two cases of patients with paratesticular fibrous pseudotumor to highlight the clinical features of this rare di...
20 CitationsSource
#1Lucas Maillette de Buy Wenniger (UvA: University of Amsterdam)H-Index: 15
Last. Ulrich Beuers (UvA: University of Amsterdam)H-Index: 66
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IgG4-related disease has properties of a systemic disorder but simultaneously is associated with a growing list of organ-specific manifestations including autoimmune pancreatitis, IgG4-associated cholangitis, IgG4-related kidney disease, and IgG4-associated prostatitis. In this study, we present, to the best of our knowledge, the first case of a patient with multiorgan IgG4-related disease who lost his testes because of IgG4-related testicular inflammation. We postulate that IgG4-related disease...
22 CitationsSource
OBJECTIVE. The objective of our study was to analyze the enhancement patterns of various intratesticular mass lesions at dynamic contrast-enhanced subtraction MRI and assess the value of the technique in distinguishing between benign and malignant lesions. MATERIALS AND METHODS. We retrospectively evaluated the records and images of 44 consecutive men (11 benign and 16 malignant intratesticular lesions) who presented to the department of urology with a variety of clinical symptoms and were refer...
37 CitationsSource
#1Phil A. Hart (Mayo Clinic)H-Index: 25
#2Ann M. Moyer (Mayo Clinic)H-Index: 17
Last. Suresh T. Chari (Mayo Clinic)H-Index: 83
view all 6 authors...
Summary In this report, we describe the first case of a patient with an IgG4–related paratesticular pseudotumor. He had histologically proven autoimmune pancreatitis, then later developed a scrotal mass. The orchiectomy specimen revealed that this was a paratesticular pseudotumor with histopathologic and immunohistochemistry findings characteristic of IgG4–related disease. Paratesticular pseudotumors are uncommon causes of intrascrotal masses and have an unexplained pathogenesis. A variety of ge...
25 CitationsSource
#1Kiyoshi MigitaH-Index: 40
#2Taiichiro MiyashitaH-Index: 20
Last. Mikio HayashiH-Index: 2
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We describe herein a patient who presented with immunoglobulin G4-related disease (IgG4-RD) involving the testis and prostate as well as the submandibular glands. Massive infiltration of IgG4-expressing plasma cells was observed in testis and prostate tissues. Serum concentrations of B cell activating factor belonging to the tumor necrosis factor family (BAFF) were elevated in parallel with serum IgG4 concentrations, and infiltration of BAFF-receptor (BAFF-R)-expressing B cells and BAFF-expressi...
15 CitationsSource
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