Cyanidin-3-O-β-glucoside polarizes LPS-induced M1 into M2 Macrophage in J774 cells via PPARγ-mediated NF-κB and STAT6 signaling pathway

Macrophage polarization exerts critical effect on inflammatory response. Cyanidin-3-O-β-glucoside (Cy-3-g), a typical anthocyanin pigment has been reported to have anti-inflammatory property. However, whether Cy-3-g exerts anti-inflammatory effects by modulating macrophage polarization remains unclear. Lipopolysaccharide (LPS) was used to establish the M1 model of J774 cells, in which the effects of Cy-3-g on M1-M2 conversion were explored....