Review paper
Molecular and Biochemical Techniques for Deciphering p53-MDM2 Regulatory Mechanisms
Abstract
The p53 and Mouse double minute 2 (MDM2) proteins are hubs in extensive networks of interactions with multiple partners and functions. Intrinsically disordered regions help to adopt function-specific structural conformations in response to ligand binding and post-translational modifications. Different techniques have been used to dissect interactions of the p53-MDM2 pathway, in vitro, in vivo, and in situ each having its own advantages and...
Paper Details
Title
Molecular and Biochemical Techniques for Deciphering p53-MDM2 Regulatory Mechanisms
Published Date
Dec 30, 2020
Journal
Volume
11
Issue
1
Pages
36 - 36
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